human papilloma virus in head and neck squamous cell cancer
نویسندگان
چکیده
background: epidemiologic and molecular evidences have established a strong link between high risk types of human papilloma virus and a subgroup of head and neck squamous cell carcinomas (hnscc). we evaluated the frequency of hpv positivity in hnscc and its relationship to demographic and some risk factor variables in an open case- control study. methods: fourteen recently diagnosed patients with squamous cell cancer of oropharynx, hypopharynx and larynx aged 18-50 years were examined from 2008-2010 in tabriz, iran. hpv dna was extracted from paraffin-embedded blocks of each patient's sample for pcr evaluation. saliva samples of 94 control cancer-free subjects were collected for dna analysis. multivariable logistic regression method was used to calculate odds ratio for case-control comparisons. results: high risk hpv was detected in 6(42.8%) patients, and 6(5.3%) control subjects which was statistically significant (p<0.0001). hpv-18 was the most frequent type both in the cases and controls. hpv-16 dna was detected in two patients of the case group, but it was not detected in any of the controls. the relation between demographic and risk factor variables was not statistically significant. conclusion: hpv infection has a significant impact on hnscc. despite hpv-16 stronger impact, hpv-18 is more likely to cause malignant degeneration in such cancers amongst some communities. it is vital to introduce and conduct immunization schedules in health care systems to protect communities to some extent.
منابع مشابه
Human Papilloma Virus in Head and Neck Squamous Cell Cancer
BACKGROUND Epidemiologic and molecular evidences have established a strong link between high risk types of Human Papilloma Virus and a subgroup of Head and Neck Squamous Cell Carcinomas (HNSCC). We evaluated the frequency of HPV positivity in HNSCC and its relationship to demographic and some risk factor variables in an open case- control study. METHODS Fourteen recently diagnosed patients wi...
متن کاملHuman papilloma virus infection in head and neck cancer.
BACKGROUND The causal link between cervical cancer and human papilloma virus (HPV) is well known. It is now becoming clear that some types of squamous-cell carcinoma of the head and neck, particularly oropharyngeal carcinoma (OPC), are also linked to HPV infection. The development of vaccines against certain HPV genotypes has changed the management strategy for HPV-associated diseases of the ut...
متن کاملDetection of Human Papilloma Virus in Head and Neck Squamous Cell Carcinomas: a Literature Review.
Human papilloma viruses (HPV) are the most common sexually transmitted viruses. There is mounting evidence that incriminates HPV as a risk factor for malignant transformation of oropharyngeal epithelium. In 2011 the International Research Agency of Cancer and National Cancer Institute (USA) declared HPV-16 as an independent risk factor for oropharyngeal squamous cell carcinoma (OPSCC). Leaders ...
متن کاملHuman Papilloma Virus: Important Etiological Factor in Head and Neck Squamous Cell Carcinogenesis
Human papilloma viruses (HPVs) are involved not only in anogenital but also in head and neck carcinogenesis. So far almost 100 sub-types of HPV have been identified but HPVs 16, 18 and 31 are most common high risk types in oro-pharyngeal cancers. Since HPVs are involved in cancers, therefore, preventive and therapeutic options will reduce the prevalence, mortality and morbidity associated with ...
متن کاملHuman Papilloma Virus-Induced Head and Neck Cancer
Head and neck cancers are a common spectrum of diseases, accounting for over one-third of a million deaths worldwide each year, and over 11,000 annual US deaths. This has typically been thought of as a disease related predominately to lifestyle choices, specifically to heavy exposures to tobacco and alcohol, and as such, has been diagnosed more in older males than in females. With increased pub...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of cancer preventionجلد ۵، شماره ۱، صفحات ۲۱-۲۶
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023